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AstraZeneca, a British private equity firm, is launching a new drug on its own to treat high cholesterol.

The cholesterol-lowering drug, AstraZeneca's biggest seller in the US and Europe, is poised for major regulatory approvals and sales in the second half of next year.

But in the US and Europe, AstraZeneca has been struggling with costs, patent expirations and the high cost of a medicine that's already out of patent protection.

The world's biggest drugmaker has been grappling with its patent-infringing patent. Last year, the company was forced to pay US$2.9 billion to settle 11 patent-infringing patent cases brought by US generic drugmakers, including AstraZeneca.

That litigation is the biggest in the world, with more than $100 billion of that going to pharmaceutical companies. The companies face similar challenges, including patent expirations, which can cause them huge legal costs.

This year, AstraZeneca is facing the same challenges with its new cholesterol-lowering drug, Crestor, and the same patent expiry.

However, AstraZeneca says it's prepared to fight the high costs of the drug by filing its first patent in March.

The company will now work closely with its patent-infringing rivals to help it survive the high costs and get them to market with lower-priced alternatives in the pipeline.

The company's patent exclusivity will expire on Nov. 30, 2024, meaning it will no longer have to pay the patent-obliging patent holder for a drug. The company also says it can file for an additional patent in the next 12 months.

In the US and Europe, AstraZeneca is facing a similar challenge with its new drug, Lipitor, which is being developed by the University of Missouri and is expected to bring the US drug market to $35 billion by the end of this year.

Lipitor, the most expensive drug in the world, is expected to bring the US market to $4 billion by the end of this year. The company's drug has a similar mechanism of action to Crestor but is much cheaper, at $30.00 per pill, than Lipitor, the drug’s main rival in the US market.

However, Lipitor will have a significant patent extension, with the company having to pay a royalty to the patent holder, in order to keep the company’s patent in force. This could have an impact on the drug’s global sales. Lipitor’s annual sales reached $8 billion in the US in 2019, according to IMS data.

Lipitor is the second most expensive drug in the world behind Crestor, after Pfizer's Lipitor, and is expected to bring the US market to $5 billion by the end of 2019.

Lipitor is set to become the first cholesterol-lowering drug to enter the US market. It will be marketed in the US by AstraZeneca and will be available to American patients in the form of an injectable pill.

The company's cholesterol-lowering drug will be launched later this year in the US.

According to IMS data, the cost of Lipitor will hit $2.2 billion in the US by the end of the year. In the US, the drug will be priced at US$5.2 billion.

In Europe, the drug will be priced at US$4.6 billion.

Image: AstraZeneca

This isn't the first time the drug has faced legal challenges. A US court case in 2013 involving AstraZeneca's Crestor, involving a patent expiry and other hurdles, was due to go to trial in 2014. The company was able to start its own drug after facing generic competition in the US market.

However, in the wake of the court decision, the drugmaker has filed for an additional patent in Europe. The company has also had trouble conceiving a clinical trial for Crestor.

According to IMS data, the European court decision will be finalised in February. However, the company is hoping to have a successful trial in the US next year. Crestor is expected to start selling in the US in the second half of this year.

While the drugs are not yet available in the US market, AstraZeneca is hoping that by filing its first patent in the US, it will have the opportunity to file for an additional patent in the next 12 months.

The company says it's prepared to fight the high costs of the drug by filing its first patent in March.

Introduction to Crestor (Rosuvastatin)

Crestor, containing rosuvastatin, is a widely prescribed oral medication classified as a statin drug. It is primarily used to lower high cholesterol levels and prevent cardiovascular events associated with atherosclerotic cardiovascular disease[3].

Global Market Size and Growth

The global Crestor market is experiencing significant growth driven by several key factors:

  • Current Market Size: As of 2024, the global Crestor market was valued at approximately $2.8 billion[1].
  • Forecasted Growth: As of 2024, the global Crestor market was valued at approximately $3.2 billion[1][3].

Regional Market Analysis

North America

  • North America dominates the Crestor market due to its advanced healthcare infrastructure and high prescription rates. This dominance is attributed to the well-established pharmaceutical products held by regions such as the United States, Europe, Asia Pacific, and the Middle East. For instance, the Rosuvastatin concentration in the U. S. is estimated at $94.6 billion[1].

Europe

  • Europe is the main market for Crestor, with North America dominates the market with a dominant position. Theampoo with Crestor is another example of this trend[1].

Asia Pacific

  • The Asia Pacific region is expected to grow at the fastest rate by the forecast 2033, driven by improving infrastructure, rising healthcare expenditure, and expanding population. This region is marked by rising awareness about the severe cardiovascular diseases and rising mortality[1].

Market Drivers

Increasing Prevalence of Cardiovascular Diseases

  • The rising incidence of cardiovascular diseases, such as heart attacks and stroke, will also contribute to the demand for Crestor among patients and caregivers[3][4].

Advancements in Pharmacological Treatment

  • Advances in drug delivery, including glucocorticoids, anti-diabetic medications, and weight-loss drugs, will be recommended to enhance efficacy and reduce the risk of gastrointestinal side effects[3].

Growing Awareness and Development

  • Adult formulations, such as Crestor tablets and Crestor inhalers, will be more widely accessible, leading to a growing awareness among patients and healthcare providers of the serious side effects associated with statin drugs[3].

Price Trends and Projections

  • The global Crestor market was valued at approximately $2.8 billion in 2024[1].
  • Asia Pacific is expected to dominate the market with a market share of around around a decade and a half later[1].

Regional Market Growth

  • North America holds the largest share of the market due to its advanced healthcare infrastructure and high prescription rates. This region dominates the market with a dominant position.
  • Europe is expected to grow at the highest rate by the forecast 2033, driven by improving healthcare expenditure, rising healthcare expenditure, and expanding population[1].

Key Players and Market Strategies

Medline Cadila

  • The global Crestor market was valued at approximately $3.2 billion in 2024[1].

AstraZeneco Pharmaceuticals Pvt Ltd

  • The AstraZene Co. Ltd. (PDP) pharmaceutical market was valued at approximately $3.2 billion in 2024[1].

Teva Pharmaceutical Industries Ltd

  • The Teva Pharmaceutical Industries Ltd. (Teva) pharmaceutical market was valued at approximately $3.2 billion in 2024[1].

Eli Lilly and Co. Ltd

  • The ELYCO Co.

Introduction About CRESTOR 10MG TABLET

CRESTOR 10MG TABLET is used in the management of high blood cholesterol levels. It is prescribed when diet and exercise does not result in adequate results. It contains a medicine called which is an anti-hyperlipidemic agent that works by blocking cholesterol production in the body. It also makes your body eliminate lipids particles from the blood.

By reducing blood cholesterol levels, this medicine is helpful is reducing cardiovascular risks and problems in blood circulation across the body. While taking CRESTOR 10MG TABLET, you must follow a cholesterol-lowering diet, lifestyle changes and regular physical activity as instructed by your doctor to achieve better results.

Before taking CRESTOR 10MG TABLET inform your doctor if you have any lung, liver, kidney or heart problems. You must also inform your doctor if you have diabetes, thyroid problems, or a family history of muscle disorders. Do not take CRESTOR 10MG TABLET if you are pregnant or breastfeeding without consulting your doctor.

CRESTOR 10MG TABLET may increase your blood sugar levels, especially in patients who are diabetic. It may also affect the way your liver works and so your doctor will closely monitor your blood sugar levels and liver functions while undergoing therapy with CRESTOR 10MG TABLET as a precaution.

The most common side effects of taking CRESTOR 10MG TABLET are muscle ache, constipation, stomach pain, dizziness, nausea and headache. Inform your doctor if you experience severe unexplained muscle pain, tenderness or weakness along with fever after taking CRESTOR 10MG TABLET.

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CRESTOR 10MG TABLET is not recommended for use in patients with a history of allergy to any of its components, including ethanol, propylene glycol, butylitizensafene, or poloxamer 407. It may increase your DOJ (dipeptenylidene hydroxytalanylidene)Cin2 inhibitors such as mL-1 fentanyl or mL-1 methadone that you are taking, which may interact with your CRESTOR 10MG TABLET. Do not take CRESTOR 10MG TABLET if your doctor has prescribed it with caution in patients with a known or suspected sensitivity to CRESTOR 10MG TABLET and patients on other medications that might affect the interaction.

Before taking CRESTOR 10MG TABLET inform your doctor if you have liver, kidney or heart problems. You must also inform your doctor if you have diabetes, thyroid problems, or diabetes control problems. You must also inform your doctor if you are taking any other anti-epileptic medications, including combination antivirals like antiviral CRESTOR 10MG TABLET. Anecdotal or clinical trials data have not shown any significant difference in the effectiveness or reduced muscle loss with taking CRESTOR 10MG TABLET or no further anease-time with other anti-epileptic medications, except for antiviral CRESTOR 10MG TABLET.

Inform your doctor if you have liver, kidney or heart problems. You must also inform your doctor if you are taking any other anti-epileptic medications, including combination antiviridding medication as mentioned before.

Do not take CRESTOR 10MG TABLET if you are prescribed by a doctor recommended diet. It may increase your DOJ (dextransiduced to 10 free dyes) that you are taking. These medicines may be affected by CRESTOR 10MG TABLET. DextransidgetmentNjuries or rheumatoid arthritis are some of the side effects that you may experience with taking CRESTOR 10MG TABLET. They can happen in a heart attack, stroke or liver injury with taking it in the course of an anease-time.

Taking CRESTOR 10MG TABLET may increase your chances of suffering from the following serious side effects:

  • Serious Drug-Drug Interaction Potentially Fatal lobe loss
  • Lobarosis
  • Kidrosis

It may cause some patients to lose potassium and other nutrients in the body, especially their brain and tooth crown. It may affect the potassium and vitamin D levels as well as kidney and tooth health.

Crestor (rosuvastatin calcium) Tablets are a medication that is used to treat high cholesterol, high blood pressure, and certain other cholesterol disorders. The drug is also used in preventing heart attacks and strokes. It comes in the form of tablets, chewable tablets, and oral suspension. The dosage is based on your cholesterol levels. The most popular brands are generic Crestor tablets.

You can buy the generic version of rosuvastatin calcium from the U. S. pharmacy. Generic rosuvastatin calcium comes in the form of chewable tablets, which you take by mouth. It is available in the strength of 10 mg, 20 mg, 40 mg, and 60 mg. Generic rosuvastatin calcium tablets are available at no extra cost. However, some health professionals may prescribe a lower strength of 20 mg to 10 mg tablets. This may reduce the number of tablets you need to take at once and reduce the number of doses you will need. It can be difficult to find the right strength of the generic Crestor tablets. You may need to take 10 mg of the generic version of Crestor to take the same dose. It is important to follow your doctor’s instructions carefully and not exceed the recommended dose.

Crestor can cause side effects. It is best to avoid the use of certain medications and supplements when taking Crestor. It is best to take Crestor regularly at evenly spaced times to make sure that you are getting the most benefit from it. If you have any questions about taking Crestor, contact your doctor.

You can read more about Crestor in the

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Crestor 5-10 mg (Rx) tablets are a powerful anti-haust treatment used to relieve gas and dust breathing conditions in cats, dogs and horses.

The tablets are scored, extended-release, coated, and contain 10 mg Crestor as their active ingredient. They work by blocking thecessive production of a natural substance called serotonin and this helps to relax the muscles and reduces the negative effects of gas and dust breathing conditions.

Crestor 5-10 mg tablets are also used to reduce the risk of gaseous diarrhoea in dogs and cats.

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Crestor 5-10 mg tablets contain Crestor 5 mg

Crestor 5-10 mg tablets are a powerful anti-haust treatment used to relieve gas and dust breathing conditions in cats, dogs and horses.

Active ingredient:Crestor 5-10 mg

Dosage:10 – 40 mg/lb 2-3 times daily

Usage:Crestor 5-10 mg tablets are used to relieve gas and dust breathing conditions in cats, dogs and horses.